Correct Answer: D
Explanation:
An elevated rate of basal hepatic glucose output is the primary determinant of elevated fasting blood glucose levels in patients with type 2 diabetes . The primary effect of metformin is the suppression of basal hepatic glucose production, thereby reducing fasting plasma glucose. Metformin does not stimulate insulin secretion; in contrast, metformin reduces fasting plasma insulin and improves whole-body insulin-stimulated glucose metabolism (insulin sensitivity). While it is possible that the beneficial effect of metformin on insulin sensitivity is mediated directly, a more likely explanation is that it is secondary to a reduction in hyperglycemia, triglycerides, and free fatty acids.
evidence has shown that metformin activates the AMP-activated protein kinase AMC MCQ
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