Weight loss Medication prevent heart attacks
The SGLT2 inhibitor family includes the following drugs:
Canagliflozin (Invokana®)
Dapagliflozin (Forxiga®)
Empagliflozin (Jardiance®)
Ertugliflozin (Steglatro®)
Kidney Benefits of SGLT2 Inhibitors
Slowing Kidney Disease Progression
SGLT2 inhibitors are effective at slowing the progression of kidney disease in people with chronic kidney disease (CKD) and type 2 diabetes.
These medications reduce the risk of kidney failure and death in individuals with CKD.
Remarkably, SGLT2 inhibitors also protect the kidneys in people with CKD who do not have diabetes.
Mechanism of Kidney Protection
When SGLT2 inhibitors remove sugar from the urine, they also flush out salt and fluid.
This reduction in salt and fluid workload on the kidneys contributes to their protective effect.
Heart Benefits of SGLT2 Inhibitors
Reducing Heart Failure Risk
SGLT2 inhibitors have emerged as powerful allies in the fight against heart failure.
They lower the risk of heart failure in people with type 2 diabetes and CKD.
By improving cardiac function, these medications enhance overall cardiovascular health.
Slowing Cardiovascular Disease Progression
A 2018 review found that SGLT2 inhibitors were linked to a lower risk of stroke, heart attack, and death from cardiovascular disease in people with type 2 diabetes and hardened arteries.
Their ability to slow the progression of cardiovascular disease makes them invaluable.
Potential Side Effects of SGLT2 Inhibitors
Common Side Effects
Hypoglycemia or low blood glucose: This usually occurs when SGLT2 inhibitors are used alongside other diabetic medications. Adjustments may be necessary to prevent hypoglycemia.
Dehydration: These medications increase urine volume, potentially causing dehydration. Stay hydrated by drinking fluids.
Urinary tract and Fungal genital infections: Increased glucose in the urine raises the risk of infections like thrush around the genital area. Proper hygiene and loose-fitting underwear can help prevent this. Also, another trick is the stick to low carbohydrate diet to reduce the amount of glucose going out with urine.
Uncommon Side Effects
Increased acid in the blood or diabetic ketoacidosis): Rare but serious, this condition can occur even when blood glucose is normal. Seek medical help if symptoms like nausea, abdominal pain, or rapid breathing arise.
Foot disease: If you’re at risk for foot problems, consult your doctor before starting or continuing SGLT2 inhibitors.
Other medications for weight loss:
Orlistat is a medication used to treat obesity by preventing the absorption of fats from the human diet. Let’s explore more about this weight loss medicine:
Orlistat acts as a lipase inhibitor, blocking enzymes in your gut that digest fat.
Approximately one-third of the fat you consume is not absorbed into your body and is instead passed out with your stools.
By reducing caloric intake, Orlistat contributes to weight loss.
Phentermine-topiramate, sold under the brand name Qsymia, is a combination drug that combines phentermine and topiramate. Let’s explore its uses, benefits, and potential side effects:
Phentermine-topiramate is used to help adults and children aged 12 years or older who are obese, or certain adults who are overweight and have weight-related medical problems, to lose weight and prevent weight regain.
It must be used alongside a reduced-calorie diet and an exercise plan.
Mechanism of Action:
Phentermine: Acts as an appetite suppressant by affecting the central nervous system. It reduces hunger and food intake.
Topiramate: Originally an antiepileptic drug, it also has weight loss effects. Its exact mechanism is not fully understood but may involve appetite regulation and altered taste perception.